期刊
BMC PSYCHIATRY
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-244X-13-72
关键词
Treatment-resistant depression; Diffusion tensor imaging; Fractional anisotropy; Voxel-based analysis method
类别
资金
- National Natural Science Foundation of China [30830046, 81171286, C090104]
- National Science and Technology Program of China [2007BAI17B02]
- National 973 Program of China [2009CB918303, 2007CB512308]
- Chinese Ministry of Education [20090162110011]
- Medical Research Foundation of Guangdong, China [A2012523]
- Science and Technology Program of Guangzhou, China [2010Y1-C631]
- Science and Technology Program of Guangdong,, China [2012B031800015]
- National Hi-Tech Research and Development Program of China (863 program) [2008AA02Z413]
Background: White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD. Approximately 30% of MDD patients demonstrate treatment-resistant depression (TRD). However, the neurobiology of TRD remains unclear. Methods: We used a voxel-based analysis method to analyze DTI data in young patients with TRD (n = 30; 19 males, 11 females) compared with right-handed, age- and sex-matched healthy volunteers (n = 25; 14 males, 11 females). Results: We found a significant decrease in fractional anisotropy (FA) (corrected, cluster size >50) in the left middle frontal gyrus (peak coordinates [-18 46-14]), left limbic lobe uncus (peak coordinates [-18 2-22]), and right cerebellum posterior lobe (peak coordinates [26-34 -40]). There was no increase in FA in any brain region in patients. We also found a significant negative correlation between mean regional FA values in the three areas and Beck Depression Inventory symptom scores. Conclusions: We found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. These data suggest that abnormalities of cortical-limbic-cerebellar white matter networks may contribute to TRD in young patients.
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