期刊
NEUROLOGY RESEARCH INTERNATIONAL
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/907409
关键词
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资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH074457] Funding Source: NIH RePORTER
- NIMH NIH HHS [R01 MH074457] Funding Source: Medline
Multimodal magnetic resonance imaging (MRI) techniques have been developed to noninvasively measure structural, metabolic, hemodynamic and functional changes of the brain. These advantages have made MRI an important tool to investigate neurodegenerative disorders, including diagnosis, disease progression monitoring, and treatment efficacy evaluation. This paper discusses recent findings of the multimodal MRI in the context of surrogate biomarkers for identifying the risk for AD in normal cognitive (NC) adults, brain anatomical and functional alterations in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients. Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.
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