期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
卷 2, 期 1, 页码 200-208出版社
KARGER
DOI: 10.1159/000338410
关键词
Alzheimer's disease; Mild cognitive impairment; Subjective cognitive impairment; Neuropsychiatric symptoms; Prevalence
资金
- Natural Science Foundation of China [30500178, 30971044, 81171018]
- Hi-tech R&D Program, Ministry of Science and Technology [2007AA02Z421]
- National Institute on Aging and Fogarty International Center [R21AG028180-01A2]
Aims: The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across the declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to explore the clinical correlates of NPS. Method: In a memory clinic, 157 subjects (46 mild AD patients, 38 MCI individuals, 24 SCI subjects, and 49 normal controls) completed the neurobehavioral assessments with the Neuropsychiatric Inventory (NPI). The clinical significance of each NPI domain was defined as an item score >= 4. Result: Clinically significant depression was more common in the SCI than in the normal control group (p < 0.05). The frequency of NPS was significantly greater in the mild AD group compared to other groups. Clinically significant apathy and aberrant motor behavior were more common among the AD group than the MCI group (p < 0.05). The MMSE score (OR 4.84, 95% CI 1.92-12.16, p = 0.001) and apathy (OR 12.73, 95% CI 1.48-109.68, p = 0.021) significantly determined the diagnostic status as MCI or mild AD. Conclusion: Across the declining memory continuum, the frequency of NPS was highest among mild AD patients. Depression, apathy, and aberrant motor behavior deserve more attention. Presence of apathy might be an independent determinant for mild AD. Copyright (C) 2012 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据