期刊
DERMATO-ENDOCRINOLOGY
卷 4, 期 2, 页码 101-108出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/derm.19859
关键词
vitamin D; sepsis; severe sepsis; critical care medicine; nutrition; infection
类别
资金
- National Institutes of Health [T32 A/1013528, K23 AR054334, K24 RR023356, R21 HL110044, U54 RR-024380, P50 AA-013757P50, A/1013757]
- Atlanta Clinical and Translational Science Institute [UL1 RR025008]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [K24RR023356, UL1RR025008] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL110044] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K23AR054334] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K24DK096574] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [T32AA013528, P50AA013757] Funding Source: NIH RePORTER
Vitamin D insufficiency and sepsis are both highly prevalent worldwide problems and this article reviews the emerging science that is defining the intersections of these conditic)ns. The importance of vitamin D's role in skeletal health has long been understood but recent evidence is beginning to highlight its role in the functioning of other physiologic systems of the body. Basic science data reveal its integral role in local immune responses to pathogens and the systemic inflam matory, pathways of sepsis. Furthermore, clinical scientists have found associations with respiratory infections, critical illness and sepsis but the causal relationship and its clinical impact have yet to be dearly defined. The article ends with speculations on the connections between racial disparities and seasonal differences in sepsis and vitamin D insufficiency.
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