期刊
FEMS MICROBIOLOGY REVIEWS
卷 36, 期 1, 页码 78-94出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2011.00286.x
关键词
morphogenesis; mating; sexual development; fungi; MAPK pathway; dimorphic fungi
类别
资金
- NIH/NIAID [AI39115, AI50113, AI50438]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050438, R01AI039115, R01AI050113, R37AI039115] Funding Source: NIH RePORTER
The ability of fungi to transition between unicellular and multicellular growth has a profound impact on our health and the economy. Many important fungal pathogens of humans, animals, and plants are dimorphic, and the ability to switch between morphological states has been associated with their virulence. Cryptococcus neoformans is a human fungal pathogen that causes life-threatening meningoencephalitis in immunocompromised and, in some cases, immunocompetent hosts. Cryptococcus neoformans grows vegetatively as a budding yeast and switches to hyphal growth during the sexual cycle, which is important in the study of cryptococcal pathogenicity because spores resulting from sexual development are infectious propagules and can colonize the lungs of a host. In addition, sexual reproduction contributes to the genotypic variability of Cryptococcus species, which may lead to increased fitness and virulence. Despite significant advances in our understanding of the mechanisms behind the development of C. neoformans, our knowledge is still incomplete. Recent studies have led to the emergence of many intriguing questions and hypotheses. In this review, we describe and discuss the most interesting aspects of C. neoformans development and address their impact on pathogenicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据