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Challenges and Opportunities for Small Molecule Aptamer Development

期刊

JOURNAL OF NUCLEIC ACIDS
卷 2012, 期 -, 页码 -

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HINDAWI LTD
DOI: 10.1155/2012/748913

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资金

  1. Alexander Wahba
  2. Natural Sciences and Engineering Council of Canada (NSERC)
  3. Canadian Foundation for Innovation (CFI)
  4. Ontario Research Fund (ORF)
  5. Ontario Early Researcher Award

向作者/读者索取更多资源

Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.

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