期刊
JOURNAL OF NUCLEIC ACIDS
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/748913
关键词
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资金
- Alexander Wahba
- Natural Sciences and Engineering Council of Canada (NSERC)
- Canadian Foundation for Innovation (CFI)
- Ontario Research Fund (ORF)
- Ontario Early Researcher Award
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
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