期刊
FEMS MICROBIOLOGY REVIEWS
卷 36, 期 1, 页码 206-231出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2011.00317.x
关键词
differentiation; development; sporulation; cell division; chromosome segregation
类别
资金
- Wenner Foundation
- Gren Foundation
- Lars Hiertas Minne Foundation
- National Institutes of Health [GM96268]
- Swedish Research Council [621-2010-4463]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R15GM096268] Funding Source: NIH RePORTER
Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae first to form specialized aerial hyphae and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from -omics studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve.
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