4.2 Article

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease

M. T. Heneka et al.

Current Alzheimer Research (2012)

Article Clinical Neurology

Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

M. T. Ferretti et al.

Current Alzheimer Research (2012)

Article Immunology

Solanezumab for the treatment of mild-to-moderate Alzheimer's disease

Bruno P. Imbimbo et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2012)

Article Geriatrics & Gerontology

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

Maria Teresa Ferretti et al.

NEUROBIOLOGY OF AGING (2012)

Article Multidisciplinary Sciences

Multi-Target Drugs: The Trend of Drug Research and Development

Jin-Jian Lu et al.

PLOS ONE (2012)

Review Neurosciences

Role of APP for dendritic spine formation and stability

Christian K. E. Jung et al.

EXPERIMENTAL BRAIN RESEARCH (2012)

Editorial Material Clinical Neurology

What the Halted Phase III γ-Secretase Inhibitor Trial May (or May Not) Be Telling Us

Nina F. Schor

ANNALS OF NEUROLOGY (2011)

Review Biochemistry & Molecular Biology

Multi-Target-Directed Ligands in Alzheimer's Disease Treatment

M. Bajda et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The γ-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease

Annamaria Lanzillotta et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

Correction Clinical Neurology

Alzheimer's disease: clinical trials and drug development (vol 9, pg 702, 2010)

F. Mangialasche et al.

LANCET NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Resolving controversies on the path to Alzheimer's therapeutics

Dennis J. Selkoe

NATURE MEDICINE (2011)

Article Cell Biology

Mapping the Road Forward in Alzheimer's Disease

David M. Holtzman et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Review Clinical Neurology

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

Gunnar K. Gouras et al.

ACTA NEUROPATHOLOGICA (2010)

Review Biochemistry & Molecular Biology

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Leslie Crews et al.

HUMAN MOLECULAR GENETICS (2010)

Article Neurosciences

Reimagining Alzheimer's Disease-An Age-Based Hypothesis

Karl Herrup

JOURNAL OF NEUROSCIENCE (2010)

Article Pharmacology & Pharmacy

Oral Treatment with a gamma-Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

Matthew Townsend et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Article Multidisciplinary Sciences

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

Tobias Bittner et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity

Ralf P. Friedrich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein

Claudia Balducci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Clinical Neurology

Alzheimer's disease: clinical trials and drug development

Francesca Mangialasche et al.

LANCET NEUROLOGY (2010)

Review Clinical Neurology

Synaptic degeneration in Alzheimer's disease

Thomas Arendt

ACTA NEUROPATHOLOGICA (2009)

Review Biochemistry & Molecular Biology

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

Hyoung-gon Lee et al.

NEUROCHEMISTRY INTERNATIONAL (2009)

Article Multidisciplinary Sciences

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Xiaoyan Hu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Pharmacology & Pharmacy

In vitro and in vivo profiling of CHF5022 and CHF5074 -: Two β-amyloid1-42 lowering agents

Bruno P. Imbimbo et al.

PHARMACOLOGICAL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?

Yan Yang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

Article Biochemistry & Molecular Biology

Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke

TV Arumugam et al.

NATURE MEDICINE (2006)

Article Multidisciplinary Sciences

A specific amyloid-β protein assembly in the brain impairs memory

S Lesné et al.

NATURE (2006)

Article Neurosciences

Dynamics of learning-induced spine redistribution along dendrites of pyramidal neurons in rats

S Knafo et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

Review Neurosciences

Intracellular A-beta amyloid, a sign for worse things to come?

V Echeverria et al.

MOLECULAR NEUROBIOLOGY (2002)