期刊
EGYPTIAN RHEUMATOLOGIST
卷 34, 期 1, 页码 19-25出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejr.2011.09.003
关键词
Systemic sclerosis; Renal involvement; Microalbuminuria; Creatinine clearance; Scleroderma Assessment; Questionnaire
类别
Introduction: Renal involvement and systemic vascular damage have been shown to be significantly affecting prognosis in systemic sclerosis. Aim of work: Microalbuminuria detection in SSc patients as an indicator of early renal involvement and its correlation with various SSc clinical, laboratory parameters and severity of organ systems' damage assessed by Scleroderma Assessment Questionnaire. Patients and methods: Forty SSc patients (33 females and 7 males) with mean age of 27.48 +/- 12.56 years and mean disease duration of 6.2 +/- 4.14 years were included. Twenty-four (60%) had lSSc; 13 (32.5%) had dSSc and 3 (7.5%) patients had SSc sine scleroderma. Results: Eight (20%) had microalbuminuria and 9 (22.5%) patients had decreased creatinine clearance. Albumin/creatinine ratio was significantly higher among dSSc patients compared to those with lSSc and SSc sine scleroderma (X-2 = 9.077; p = 0.01). Albumin/creatinine ratio showed significant positive correlations with telangiectasia (r = 0.322; p = 0.04) and mRodnan's skin score (r = 0.352; p = 0.026) and negative correlations with inter-incisor distance (r = -0.525; p = 0.001) and pleurisy (r = -0.446; p = 0.004). Albumin/ creatinine ratio correlated significantly and positively with IMSS and IDS indices of SAQ (r = 0.378, 0.32; p = 0.016, 0.044, respectively). SSc patients with microalbuminuria showed significantly higher mean IDS than those without (1.058 vs. 0.631, p = 0.04). No statistically significant correlations were found between creatinine clearance and the different demographic, clinical features and the indices of SAQ. Conclusion: Microalbuminuria compared to creatinine clearance may be a more sensitive indicator of early renal affection and predictor of increased morbidity. (C) 2011 Egyptian Society for Joint Diseases and Arthritis. Production and hosting by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据