期刊
BMC NEUROSCIENCE
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2202-9-97
关键词
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资金
- Hjarnfonden (Brain Research Foundation)
- Swedish Research Foundation
- Novo Nordisk
- NIH [NS-49479]
- FEDER/Portuguese Foundation for Science and Technology [POCTI/SAU-NEU/56618/2004]
- FCT
- Fundação para a Ciência e a Tecnologia [POCI/SAU-NEU/56618/2004] Funding Source: FCT
Background: GPR125 belongs to the family of Adhesion G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125. Results: We found specific expression of GPR125 in cells of the choroid plexus using in situ hybridization and protein-specific antibodies and combined in situ/immunohistochemistry co-localization using cytokeratin, a marker specific for epithelial cells. Induction of inflammation by LPS did not change GPR125 expression. However, GPR125 expression was transiently increased ( almost 2-fold) at 4 h after traumatic brain injury (TBI) followed by a decrease ( approximately 4-fold) from 2 days onwards in the choroid plexus as well as increased expression ( 2-fold) in the hippocampus that was delayed until 1 day after injury. Conclusion: These findings suggest that GPR125 plays a functional role in choroidal and hippocampal response to injury.
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