期刊
CLINICAL MEDICINE INSIGHTS-CARDIOLOGY
卷 6, 期 -, 页码 17-33出版社
SAGE PUBLICATIONS LTD
DOI: 10.4137/CMC.S4324
关键词
rosuvastatin; cardiovascular risk; statins; low density lipoprotein cholesterol
Rosuvastatin is a new generation HMG-CoA reductase inhibitor which exhibits some unique pharmacologic and pharmacokinetic properties. It has low extrahepatic tissue penetration, low potential for CYP3A4 interactions and substantial LDL-C lowering capacity and therefore has distinct advantages. We conducted a Medline literature search to identify rosuvastatin papers published in English. In this review, we outline the pharmacology of rosuvastatin, highlighting its efficacy and safety. We also review the major clinical trials with reference to primary and secondary prevention, familial hypercholesterolaemia and comparison with other statins. Finally we address its place in clinical practice.
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