期刊
VASCULAR CELL
卷 4, 期 -, 页码 -出版社
BMC
DOI: 10.1186/2045-824X-4-13
关键词
Macrophage; Angiogenesis; Wnt
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL060067] Funding Source: NIH RePORTER
Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype.
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