期刊
BMC MICROBIOLOGY
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12866-018-1257-x
关键词
Asthma; MWAS; Eggerthella lenta; Faecalibacterium prausnitzii; SCFAs
类别
资金
- Wellcome Trust [105022/Z/14/Z]
- National Institute for Health Research (NIHR) BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- Shenzhen Municipal Government of China [CXB201108250098A, JCYJ20170817145809215]
- MRC [MR/N01183X/1] Funding Source: UKRI
- Wellcome Trust [105022/Z/14/Z] Funding Source: Wellcome Trust
Background: Asthma, one of the most common chronic respiratory disorders, is associated with the hyper-activation of the T-cell subset of adaptive immunity. The gut microbiota may be involved in the development of asthma through the production of short-chain fatty acids (SCFAs), exhibiting modulatory effects on Th. So, we performed a metagenome-wide association study (MWAS) of the fecal microbiota from individuals with asthma and healthy controls. And that was the first case to resolve the relationship between asthma and microbiome among UK adults. Results: The microbiota of the individuals with asthma consisted of fewer microbial entities than the microbiota of healthy individuals. Faecalibacterium prausnitzii, Sutterella wadsworthensis and Bacteroides stercoris were depleted in cases, whereas Clostridiums with Eggerthella lenta were over-represented in individuals with asthma. Functional analysis shows that the SCFAs might be altered in the microbiota of asthma patients. Conclusion: In all, the adult human gut microbiome of asthma patients is clearly different from healthy controls. The functional and taxa results showed that the change of asthma patients might related to SCFAs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据