Calculating cardiac risk in obese adolescents before and after onset of lifestyle intervention

Prevalence and severity of obesity in adolescents is increasing worldwide. The obesity-associated cardiovascular risk factors (CRF) determine cardiac risk as demonstrated by longitudinal studies. Fat distribution and not overall fat mass determines the cardiac risk, since intra-abdominal adipose tissue is especially related to CRFs. Besides classical CRFs such as hypertension, dyslipidemia and impaired glucose metabolism, a proinflammatory and prothrombotic state in obesity is associated with cardiac risk. Adipocytokines such as adiponectin are related to cardiac risk and may present useful predictors of cardiac mortalities in future. Measurement of the carotid intima- media thickness is a new promising noninvasive marker for early cardiovascular changes including atherosclerosis. The therapy of choice to prevent cardiac events in obesity is lifestyle intervention of obese adolescents. However, in clinical practice, the weight loss in lifestyle interventions is only moderate and drug treatment of CRFs is seldom performed.