期刊
BIOINFORMATION
卷 9, 期 7, 页码 363-367出版社
BIOMEDICAL INFORMATICS
DOI: 10.6026/97320630009363
关键词
Phylogenetic trees; Metabolome; Hierarchical clustering; Interacting pathways
资金
- FDR major grant
- FDR mini grant at East Stroudsburg University, USA
- President Research Fund
Phylogenetic trees are used to represent evolutionary relationships among biological species or organisms. The construction of phylogenetic trees is based on the similarities or differences of their physical or genetic features. Traditional approaches of constructing phylogenetic trees mainly focus on physical features. The recent advancement of high-throughput technologies has led to accumulation of huge amounts of biological data, which in turn changed the way of biological studies in various aspects. In this paper, we report our approach of building phylogenetic trees using the information of interacting pathways. We have applied hierarchical clustering on two domains of organisms-eukaryotes and prokaryotes. Our preliminary results have shown the effectiveness of using the interacting pathways in revealing evolutionary relationships.
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