期刊
BMC MEDICINE
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1741-7015-12-7
关键词
Stress; Life events; Childhood maltreatment; Childhood adversity; Child abuse; Depression; Brain-derived; neurotrophic factor; BDNF; rs6265; Gene-environment interaction
资金
- Medical Research Council (MRC)
- Economic Social Research Council (ESRC) UK Interdisciplinary Postdoctoral Fellowship [PTA-037-27-0165]
- Canada Research Chairs program
- ESRC [ES/H04678X/1] Funding Source: UKRI
- Economic and Social Research Council [ES/H04678X/1] Funding Source: researchfish
- Medical Research Council [G9817803B] Funding Source: researchfish
Background: Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has received much attention. The aim of the present work was to review and conduct a meta-analysis on the results from published studies examining this interaction. Methods: A literature search was conducted using PsychINFO and PubMed databases until 22 November 2013. A total of 22 studies with a pooled total of 14,233 participants met the inclusion criteria, the results of which were combined and a meta-analysis performed using the Liptak-Stouffer z-score method. Results: The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). When the studies were stratified by type of environmental stressor, the evidence was stronger for an interaction with stressful life events (P = 0.01) and weaker for interaction of BDNF Val66Met with childhood adversity (P = 0.051). Conclusions: The interaction between BDNF and life stress in depression is stronger for stressful life events rather than childhood adversity. Methodological limitations of existing studies include poor measurement of life stress. Keywords: Stress, Life events, Childhood maltreatment, Childhood adversity, Child abuse, Depression, Brain-derived neurotrophic factor, BDNF, rs6265, Gene-environment interaction
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