期刊
BMC MEDICINE
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12916-014-0130-5
关键词
Cardiovascular disease; Imaging markers; Risk factors; Dementia; Alzheimer's disease
资金
- Netherlands Heart Foundation [2012 T008]
- Internationale Stichting Alzheimer Onderzoek [12533]
- Erasmus MC Fellowship
- MRACE grant from Erasmus MC
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people, but there are still no curative options. Senile plaques and neurofibrillary tangles are considered hallmarks of AD, but cerebrovascular pathology is also common. In this review, we summarize findings on cardiovascular disease (CVD) and risk factors in the etiology of AD. Firstly, we discuss the association of clinical CVD (such as stroke and heart disease) and AD. Secondly, we summarize the relation between imaging makers of pre-clinical vascular disease and AD. Lastly, we discuss the association of cardiovascular risk factors and AD. We discuss both established cardiovascular risk factors and emerging putative risk factors, which exert their effect partly via CVD.
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