期刊
BMC MEDICINE
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1741-7015-10-154
关键词
anti-inflammatory; cytokines; depression; hypercholesterolemia; mood; oxidative; statins
资金
- Brain and Behaviour Research Institute
- National Health and Medical Research Council
- Australian Rotary Health
- Geelong Medical Research Foundation
- Ian Potter Foundation
- Eli Lilly
- University of Melbourne
- NIH
- Simons Foundation
- CRC for Mental Health
- Stanley Medical Research Institute
- MBF
- NHMRC
- Beyond Blue
- Bristol Myers Squibb
- Glaxo SmithKline
- Organon
- Novartis
- Mayne Pharma
- Servier
- Astra Zeneca
- Pfizer
- Deakin University
- Amgen
- Sanofi-Aventis
- Geelong Region Medical Research Foundation
- Barwon Health
- Perpetual Trustees
- Dairy Research and Development Corporation
- Ronald Geoffrey Arnott Foundation
- ANZ Charitable Trust
- American Society for Bone and Mineral Research
- Amgen (Europe) GmBH
- National Health and Medical Research Council (NHMRC) [1021347]
- Australian Research Council [FT991524]
- NHMRC [628912]
- Alfred Deakin Postdoctoral Research Fellowship
Background: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia. Methods: Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model. Results: The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24). Conclusions: Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.
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