期刊
BMC MEDICINE
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1741-7015-10-104
关键词
Cathelicidin; defensin; influenza; hemagglutinin; neuraminidase; NSAID; oseltamivir; siRNA; zanamivir
资金
- National Institute of Health [AI059267]
Influenza has a long history of causing morbidity and mortality in the human population through routine seasonal spread and global pandemics. The high mutation rate of the RNA genome of the influenza virus, combined with assortment of its multiple genomic segments, promote antigenic diversity and new subtypes, allowing the virus to evade vaccines and become resistant to antiviral drugs. There is thus a continuing need for new anti-influenza therapy using novel targets and creative strategies. In this review, we summarize prospective future therapeutic regimens based on recent molecular and genomic discoveries.
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