期刊
FRONTIERS IN SYSTEMS NEUROSCIENCE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2013.00102
关键词
critical period reopening; learning; absolute pitch; valproate; histone-deacetylase inhibitors; human adults
资金
- Human Frontiers Science Program (HFSP) [RGP0018/2007-C]
- Michael Smith Foundation for Health Research
- Coast Capital Savings Depression Research Fund
- Quinn Fellowship
Absolute pitch, the ability to identify or produce the pitch of a sound without a reference point, has a critical period, i.e., it can only be acquired early in life. However, research has shown that histone-deacetylase inhibitors (HDAC inhibitors) enable adult mice to establish perceptual preferences that are otherwise impossible to acquire after youth. In humans, we found that adult men who took valproate (VPA) (a HDAC inhibitor) learned to identify pitch significantly better than those taking placebo-evidence that VPA facilitated critical-period learning in the adult human brain. Importantly, this result was not due to a general change in cognitive function, but rather a specific effect on a sensory task associated with a critical-period.
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