期刊
GUT MICROBES
卷 4, 期 6, 页码 494-504出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.26277
关键词
Helicobacter pylori; children; hypochlorhydria; iron deficiency; diarrhea; growth retardation; malabsorption; cognitive impairment; developing countries
资金
- European Union [INCO-DEV-3-032136]
Helicobacter pylori infection is predominantly acquired early in life. The prevalence of the infection in childhood is low in developed countries, whereas in developing countries most children are infected by 10 y of age. In poor resource settings, where malnutrition, parasitic/enteropathogen and H. pylori infection co-exist in young children, H. pylori might have potentially more diverse clinical outcomes. This paper reviews the impact of childhood H. pylori infection in developing countries that should now be the urgent focus of future research. The extra-gastric manifestations in early H. pylori infection in infants in poor resource settings might be a consequence of the infection associated initial hypochlorhydria. The potential role of H. pylori infection on iron deficiency, growth impairment, diarrheal disease, malabsorption and cognitive function is discussed in this review.
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