期刊
GUT MICROBES
卷 4, 期 2, 页码 146-151出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.23443
关键词
mucosal immunology; bacterial infection; host defense; TNF receptor; intraepithelial lymphocyte
资金
- NIH [RO1-AI061516, PO1 DK46763, F32-DK082249]
- La Jolla Institute for Allergy and Immunology, the Center for Infectious Disease [LIAI-JAN-2011-CID]
The herpes virus entry mediator (HVEM or CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14. We have recently provided evidence showing a novel signaling pathway downstream of HVEM leading to signal transducer and activator of transcription 3 ( STAT3) activation in epithelial cells.(1) As STAT3 regulates the expression of genes important for host defense in epithelial cells, 2-4 as well as the differentiation of retinoid-related orphan receptor (ROR)gamma t(+) Th17 and innate lymphoid cells (ILC),(5-10) our finding that HVEM activates STAT3 has revealed fresh insights into the potential regulatory function of HVEM in different cellular contexts. Therefore, although further investigations will be required, HVEM is emerging as a major player in mucosal host defense, capable of regulating several cellular responses.
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