期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 42, 页码 23418-23422出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b08924
关键词
liquid crystal; thrombin; nickel nanoparticles; biosensor; signal enhancement
资金
- National Natural Science Foundation of China [51203005]
- New Teacher Fund for Doctor Station, Ministry of Education of China [20121102120045]
- Fundamental Research Funds for the Central Universities of China
A new liquid-crystal (LC)-based sensor operated by nickel nanosphere (NiNS)-induced homeotropic alignment for the label-free monitoring of thrombin was reported. When doped with NiNSs, a uniform vertical orientation of 4-cyano-4'-pentylbiphenyl (5CB) was easily obtained. A sandwich system of aptamer/thrombin/aptamer-functionalized gold nanoparticles (AuNPs) was fabricated, and AuNPs aptamer conjugation caused the disruption of the 5CB orientation, leading to an obvious change of the optical appearance from a dark to a bright response to thrombin concentrations from 0.1 to 100 nM. This design also allowed quantitative detection of the thrombin concentration. This distinctive and sensitive thrombin LC sensor provides a new principle for building LC-sensing systems.
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