期刊
BMC MEDICAL GENOMICS
卷 5, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1755-8794-5-56
关键词
Autism; Autistic disorder; Autism spectrum disorders; Autism genetics; Autism genomics; Network biology; Network medicine; Translational bioinformatics; Protein-protein interactions
资金
- National Science Foundation [0543480, 0640809]
- National Institutes of Health [LM009261]
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0543480, 0640809] Funding Source: National Science Foundation
Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. Description: We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis. Conclusions: Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders. Availability: http://autworks.hms.harvard.edu/
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据