期刊
INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/936593
关键词
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资金
- NSF-GRFP
- NCI [P30-CA016086]
- NIH [R01EB009066, R01CA170665, R43CA165621]
- Canadian Institutes of Health Research
- Ontario Research Fund
- VisualSonics
- NATIONAL CANCER INSTITUTE [R01CA170665, R43CA165621, P30CA016086] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB009066] Funding Source: NIH RePORTER
The purpose of this paper is to provide the biomedical imaging community with details of a new high resolution contrast imaging approach referred to as acoustic angiography. Through the use of dual-frequency ultrasound transducer technology, images acquired with this approach possess both high resolution and a high contrast-to-tissue ratio, which enables the visualization of microvascular architecture without significant contribution from background tissues. Additionally, volumetric vessel-tissue integration can be visualized by using b-mode overlays acquired with the same probe. We present a brief technical overview of how the images are acquired, followed by several examples of images of both healthy and diseased tissue volumes. 3D images from alternate modalities often used in preclinical imaging, contrast-enhanced micro-CT and photoacoustics, are also included to provide a perspective on howacoustic angiography has qualitatively similar capabilities to these other techniques. These preliminary images provide visually compelling evidence to suggest that acoustic angiography may serve as a powerful new tool in preclinical and future clinical imaging.
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