期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 22, 期 3, 页码 474-478出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2014.09.016
关键词
Acute stroke; Nationwide inpatient sample; Primary brain tumors; Thrombolysis
Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were identified from the 2002-2011 USA Nationwide Inpatient Sample. We compared demographics, comorbidities, and outcomes between primary brain tumor-associated strokes (BTS) and non-brain tumor associated strokes (NBTS). The main outcomes were inpatient mortality, home discharge and intracranial hemorrhage (ICH) rate. Of the 124,083 thrombolysis-treated stroke patients, 416 (0.34%) had brain tumors. In adjusted analysis, inpatient mortality (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.77-1.26, p = 0.918), rate of home discharge (OR: 1.15; 95% Cl: 0.87-1.53, p = 0.40) and rate of ICH (OR: 0.94; 95% CI: 0.62-1.44, p = 0.801) were similar between BTS and NBTS. Analysis of brain tumor subtypes showed that compared to NBTS, malignant BTS were independently associated with higher in-hospital mortality (OR: 2.51; 95% CI: 1.66-3.79, p <0.001), lower home discharge (OR: 0.36, 95% CI: 0.18-0.72, p = 0.004), and increased risk of ICH (OR: 2.33, 95% Cl: 1.49-3.65, p < 0.001). Additionally, among the BTS, intraparenchymal location of tumor was associated with higher mortality (OR: 2.51; 95% CI: 1.20-5.23, p = 0.014) and lower home discharge (OR: 0.26; 95% CI: 0.13-0.53, p < 0.001). Thrombolytic therapy for acute stroke appears to be safe in patients with primary brain tumors, with similar rates of ICH. Malignant BTS have worse outcomes, while benign BTS have outcomes comparable to NBTS. Careful consideration of tumor pathology may aid selection of patients with poor thrombolysis outcomes. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据