期刊
BMC GENOMICS
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2164-14-623
关键词
Candida glabrata; Fungal pathogens; Nakaseomyces; Yeast genomes; Yeast evolution
资金
- European Research Council under the European Union [310325]
- Qatar National Research Fund [NPRP 5-298-3-086]
- Spanish Ministry of Economy and Competitiveness [BIO2012-37161]
- University Paris Sud
- Marie Curie grant [FP7-PEOPLE-2010-IEF-No.274223]
- Region Ile-de-France's DIM Malinf program
- Instituto Gulbenkian de Ciencia, Portugal
- Fundacao Calouste Gulbenkian, Siemens SA
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/33528/2008]
- European Research Council (ERC) [310325] Funding Source: European Research Council (ERC)
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33528/2008] Funding Source: FCT
Background: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C. glabrata being part of the Nakaseomyces, a group more closely related to Saccharomyces cerevisiae. Although C. glabrata was thought to be the only pathogenic Nakaseomyces, two new pathogens have recently been described within this group: C. nivariensis and C. bracarensis. To gain insight into the genomic changes underlying the emergence of virulence, we sequenced the genomes of these two, and three other non-pathogenic Nakaseomyces, and compared them to other sequenced yeasts. Results: Our results indicate that the two new pathogens are more closely related to the non-pathogenic N. delphensis than to C. glabrata. We uncover duplications and accelerated evolution that specifically affected genes in the lineage preceding the group containing N. delphensis and the three pathogens, which may provide clues to the higher propensity of this group to infect humans. Finally, the number of Epa-like adhesins is specifically enriched in the pathogens, particularly in C. glabrata. Conclusions: Remarkably, some features thought to be the result of adaptation of C. glabrata to a pathogenic lifestyle, are present throughout the Nakaseomyces, indicating these are rather ancient adaptations to other environments. Phylogeny suggests that human pathogenesis evolved several times, independently within the clade. The expansion of the EPA gene family in pathogens establishes an evolutionary link between adhesion and virulence phenotypes. Our analyses thus shed light onto the relationships between virulence and the recent
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据