期刊
GUT MICROBES
卷 5, 期 1, 页码 71-73出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.27129
关键词
inflammatory bowel disease; irritable bowel syndrome; necrotizing enterocolitis; enteric pathogens; Enterobacteriaceae; dysbiosis
资金
- Public Health Service [AI103248, AI107393, AI096528]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI107393, R01AI096528, R21AI103248] Funding Source: NIH RePORTER
The bacterial microbiota of the human large bowel is a complex ecosystem consisting of several hundred, mostly anaerobic, species. To maintain colonization of the gut lumen and maximize growth in the presence of nutritional competitors, highly diverse metabolic pathways have evolved, with each microbeutilizingadifferentwinning strategy for nutrient acquisition and utilization. Conditions and diseases leading to intestinal inflammation are accompanied by a severe disruption the microbiota composition characterized by an expansion of facultative anaerobic Enterobacteriaceae. Here, we review evidence that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammation-derived nutrients.
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