期刊
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
卷 68, 期 1, 页码 50-56出版社
AMER OCCUPATIONAL THERAPY ASSOC, INC
DOI: 10.5014/ajot.2014.009035
关键词
activities of daily living; Alzheimer disease; exercise therapy; occupational therapy; treatment outcome
资金
- NICHD NIH HHS [K01 HD060912, 1K01HD060912] Funding Source: Medline
- NINDS NIH HHS [R01 NS042859, 5R01NS042859-06A2] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K01HD060912] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042859] Funding Source: NIH RePORTER
OBJECTIVE. Alzheimer's disease (AD) results in a loss of independence in activities of daily living (ADLs), which in turn affects the quality of life of affected people and places a burden on caretakers. Limited reearch has examined the influence of physical training (aerobic, balance, and strength training) on ADL performance of people with AD. METHOD. Six randomized controlled trials (total of 446 participants) fit the inclusion criteria. For each study, we calculated effect sizes for primary and secondary outcomes. RESULTS. Average effect size (95% confidence interval) for exercise on the primary outcome (ADL performance) was 0.80 (p <.001). Exercise had a moderate impact on the secondary outcome of physical function (effect size = 0.53, p =.004). CONCLUSION. Occupational therapy intervention that includes aerobic and strengthening exercises may help improve independence in ADLs and improve physical performance in people with AD. Additional research is needed to identify specific components of intervention and optimal dosage to develop clinical guidelines.
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