期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 1, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/23723548.2014.960754
关键词
AEP; DNA; lesions; polymerase; primase; PrimPol; replication; repriming; restart; TLS
类别
资金
- Biotechnology and Biological Sciences Research Council
- Medical Research Council
The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.
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