期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 1, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/23723548.2014.968507
关键词
AMPK; HCC; mTORC1; NASH; PPAR alpha
类别
资金
- NIH [R01AA02172, R01DK085252, P42 ES010337]
In addition to regulating the activation of nuclear factor (NF)-kB and c-Jun N-terminal kinase (JNK), TGF-beta activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy. In the liver, TAK1-mediated autophagy plays a role in preventing excessive lipid accumulation induced by starvation and fat overload. TAK1-mediated autophagy and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) prevent liver fibrosis and tumor development.
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