期刊
BMC EVOLUTIONARY BIOLOGY
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2148-13-254
关键词
Host-parasite coevolution; Red Queen hypothesis; Lotka-Volterra dynamics; Genetic drift; Population bottleneck
资金
- Emmy-Noether program of the Deutsche Forschungsgemeinschaft
- Max Planck Society
- Deutsche Forschungsgemeinschaft [SPP1399, SCHU 1415/8]
Background: Host-parasite coevolution is generally believed to follow Red Queen dynamics consisting of ongoing oscillations in the frequencies of interacting host and parasite alleles. This belief is founded on previous theoretical work, which assumes infinite or constant population size. To what extent are such sustained oscillations realistic? Results: Here, we use a related mathematical modeling approach to demonstrate that ongoing Red Queen dynamics is unlikely. In fact, they collapse rapidly when two critical pieces of realism are acknowledged: (i) population size fluctuations, caused by the antagonism of the interaction in concordance with the Lotka-Volterra relationship; and (ii) stochasticity, acting in any finite population. Together, these two factors cause fast allele fixation. Fixation is not restricted to common alleles, as expected from drift, but also seen for originally rare alleles under a wide parameter space, potentially facilitating spread of novel variants. Conclusion: Our results call for a paradigm shift in our understanding of host-parasite coevolution, strongly suggesting that these are driven by recurrent selective sweeps rather than continuous allele oscillations.
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