期刊
SAGE OPEN MEDICINE
卷 2, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2050312114546520
关键词
Sleep; sleep apnea; mild cognitive impairment; Alzheimer's disease; amyloid; positron emission tomography
资金
- Synapses, Circuits and Cognitive Disorders Award from the Brain Science Institute at Johns Hopkins University
- National Institute on Aging [AG038893]
- Mentored Research Scientist Development Award from the National Institute on Aging [1K01AG033195]
- NIH NIDA career award [K24 DA000412]
- NIH [K08NS059671, R01NS079584]
- Burroughs-Wellcome Fund Career Award for Medical Scientists
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS079584, K08NS059671] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K01AG033195, R01AG038893, R01AG041633, P50AG005146] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K24DA000412] Funding Source: NIH RePORTER
Background/aims: Although disturbed sleep is associated with cognitive deficits, the association between sleep disturbance and Alzheimer's disease pathology is unclear. In this pilot study, we examined the extent to which sleep duration, sleep quality, and sleep-disordered breathing are associated with beta-amyloid (A beta) deposition in the brains of living humans. Methods: We studied 13 older adults (8 with normal cognition and 5 with mild cognitive impairment). Participants completed neuropsychological testing, polysomnography, and A beta imaging with [C-11]-Pittsburgh compound B. Results: Among participants with mild cognitive impairment, higher apnea-hypopnea index and oxygen desaturation index were associated with greater A beta deposition, globally and regionally in the precuneus. There were no significant associations between sleep-disordered breathing and A beta deposition among cognitively normal participants. There were no significant associations between sleep duration or sleep fragmentation and A beta deposition. Conclusion: These preliminary results suggest that among older adults with mild cognitive impairment, greater sleepdisordered breathing severity is associated with greater A beta deposition.
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