期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 125, 期 1, 页码 25-32出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI73939
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资金
- NIH [GM51586, CA18941]
- NATIONAL CANCER INSTITUTE [R01CA108941] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM051586] Funding Source: NIH RePORTER
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.
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