期刊
BMC DEVELOPMENTAL BIOLOGY
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-213X-11-64
关键词
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资金
- National Natural Science Foundation of China [30900776, 30771139]
- Shanghai Natural Science Foundation [09ZR1416200]
- Science and Technology Commission of Shanghai Municipality [10DZ2270600]
- Shanghai Leading Academic Discipline Project [S30201]
Background: There have been increasing attentions on the role of small RNAs, especially microRNAs in post-transcriptional gene regulation during spermatogenesis. MicroRNA-184 (miR-184) has been shown to be mainly expressed in the testis and brain, and that its expression levels are by far the highest in the testis. However, the role of miR-184 in mammalian spermatogenesis remains unclear. Results: In this study, we demonstrated that miR-184 levels were increased during mouse postnatal testis development. Specifically, miR-184 expression was restricted to the germ cells from spermatogonia to round spermatids. Overexpression of miR-184 promoted the proliferation of a germ cell line, GC-1spg. Moreover, miR-184 downregulated nuclear receptor corepressor 2 (Ncor2) by targeting its 3' untranslated region through inhibiting NCOR2 protein translation. Conclusions: MiR-184 may be involved in the post-transcription regulation of mRNAs such as Ncor2 in mammalian spermatogenesis.
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