期刊
CLINICAL PROTEOMICS
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1559-0275-11-18
关键词
Glycosylation; Disease proteomics; Mass spectrometry
资金
- NST [2012CB910602, 2012AA020203]
- NSF [21025519, 21335002, 21375026]
- Ph.D. Programs Foundation of Ministry of Education of China [20130071110034]
- Shanghai Projects (Grants Eastern Scholar)
- Shanghai Projects [B109]
Glycosylation is estimated to be found in over 50% of human proteins. Aberrant protein glycosylation and alteration of glycans are closely related to many diseases. More than half of the cancer biomarkers are glycosylated-proteins, and specific glycoforms of glycosylated-proteins may serve as biomarkers for either the early detection of disease or the evaluation of therapeutic efficacy for treatment of diseases. Glycoproteomics, therefore, becomes an emerging field that can make unique contributions to the discovery of biomarkers of cancers. The recent advances in mass spectrometry (MS)-based glycoproteomics, which can analyze thousands of glycosylated-proteins in a single experiment, have shown great promise for this purpose. Herein, we described the MS-based strategies that are available for glycoproteomics, and discussed the sensitivity and high throughput in both qualitative and quantitative manners. The discovery of glycosylated-proteins as biomarkers in some representative diseases by employing glycoproteomics was also summarized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据