期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 125, 期 3, 页码 939-948出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI76305
关键词
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资金
- Rosetrees Trust
- National Institute of Health Research University College London Hospitals Biomedical Research Centre
Bariatric surgery is the most effective treatment for severe obesity, producing marked sustained weight loss with associated reduced morbidity and mortality. Roux-en-Y gastric bypass surgery (RYGBP), the most commonly performed procedure, was initially viewed as a hybrid restrictive-malabsorptive procedure. However, over the last decade, it has become apparent that alternative physiologic mechanisms underlie its beneficial effects. RYGBP-induced altered feeding behavior, including reduced appetite and changes in taste/food preferences, is now recognized as a key driver of the sustained postoperative weight loss. The brain ultimately determines feeding behavior, and here we review the mechanisms by which RYGBP may affect central appetite-regulating pathways.
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