期刊
JOURNAL OF EXTRACELLULAR VESICLES
卷 3, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.3402/jev.v3.23262
关键词
Isolation; RNA; lipoproteins; extracellular vesicles
类别
资金
- EMRP (European Metrology Research Programme)
- EMRP within EURAMET
- European Union
Extracellular vesicles (EVs) facilitate intercellular communication by carrying bioactive molecules such as proteins, messenger RNA, and micro (mi) RNAs. Recently, high-density lipoproteins (HDL) isolated from human plasma were also reported to transport miRNA to other cells. HDL, when isolated from human plasma, ranges in density between 1.063 and 1.21 g/mL, which grossly overlap with the reported density of EVs. Consequently, HDL and EV will be co-isolated when using density gradient ultracentrifugation. Thus, more stringent isolation/separation procedures of EV and HDL are essential to know their relative contribution to the pool of circulating bioactive molecules.
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