期刊
BMC CELL BIOLOGY
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2121-9-59
关键词
-
类别
资金
- Canadian Institutes for Health Research
- Fonds de la Recherche en Sante du Quebec
Background: Aggresomes are juxtanuclear inclusion bodies that have been proposed to represent a general cellular response to misfolded proteins in mammalian cells. Yet, why aggresomes are not a pathological characteristic of protein misfolding diseases is unclear. Here, we investigate if a misfolded protein inevitably forms aggresomes in mammalian cells. Results: We show that a cytoplasmic form of the prion protein may form aggresomes or dispersed aggregates in different cell lines. In contrast to aggresomes, the formation of dispersed aggregates is insensitive to histone deacetylase 6 inhibitors and does not result in cytoskeleton rearrangements. Modulation of expression levels or proteasome inhibitors does not alter the formation of dispersed aggregates. Conclusion: Our results establish that aggresomes are not obligatory products of protein misfolding in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据