4.4 Article

Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects

期刊

BMC CARDIOVASCULAR DISORDERS
卷 13, 期 -, 页码 -

出版社

BIOMED CENTRAL LTD
DOI: 10.1186/1471-2261-13-102

关键词

Arterial stiffness; Cardiac output; Heart rate; Head-up tilt; Systemic vascular resistance

资金

  1. Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital
  2. Finnish Cultural Foundation
  3. Finnish Foundation for Cardiovascular Research
  4. Sigrid Juselius Foundation
  5. Tampere Tuberculosis Foundation
  6. Paavo Nurmi Foundation
  7. Aarne Koskelo Foundation
  8. Finnish Medical Foundation
  9. Orion-Farmos Research Foundation

向作者/读者索取更多资源

Background: High resting heart rate (HR) is associated with increased cardiovascular risk in general populations, possibly due to elevated blood pressure (BP) or sympathetic over-activity. We studied the association of resting HR with cardiovascular function, and examined whether the hemodynamics remained similar during passive head-up tilt. Methods: Hemodynamics were recorded using whole-body impedance cardiography and continuous radial pulse wave analysis in 522 subjects (age 20-72 years, 261 males) without medication influencing HR or BP, or diagnosed diabetes, coronary artery, renal, peripheral arterial, or cerebrovascular disease. Correlations were calculated, and results analysed according to resting HR tertiles. Results: Higher resting HR was associated with elevated systolic and diastolic BP, lower stroke volume but higher cardiac output and work, and lower systemic vascular resistance, both supine and upright (p < 0.05 for all). Subjects with higher HR also showed lower supine and upright aortic pulse pressure and augmentation index, and increased resting pulse wave velocity (p < 0.001). Upright stroke volume decreased less in subjects with highest resting HR (p < 0.05), and cardiac output decreased less in subjects with lowest resting HR (p < 0.009), but clear hemodynamic differences between the tertiles persisted both supine and upright. Conclusions: Supine and upright hemodynamic profile associated with higher resting HR is characterized by higher cardiac output and lower systemic vascular resistance. Higher resting HR was associated with reduced central wave reflection, in spite of elevated BP and arterial stiffness. The increased cardiac workload, higher BP and arterial stiffness, may explain why higher HR is associated with less favourable prognosis in populations.

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