期刊
INTERNATIONAL JOURNAL OF BIOMATERIALS
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/157952
关键词
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资金
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- FUNDUNESP (Fundacao para o Desenvolvimento da UNESP)
- PROPe/UNESP (Pro-Reitoria de Pesquisa da UNESP)
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo),(Brazil) [2011/17411-8]
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.
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