期刊
BMC CANCER
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2407-14-776
关键词
Liver transplantation; Head and neck cancer; Standardized incidence ratio; Meta-analysis
类别
资金
- National Natural Science Foundation of China [81172694, 81473013, 81270537]
- Outstanding Youth Fund of Jiangsu Province [SBK2014010296]
- Chinese Ministry of Education [213015A]
- Qinglan Project of Jiangsu Province [JX2161015124]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Background: It is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer. This comprehensive meta-analysis evaluated the association between liver transplantation and the risk of head and neck cancer using data from all available studies. Methods: PubMed and Web of Science were systematically searched to identify all relevant publications up to March 2014. Standardized incidence ratio (SIR) and 95% confidence intervals (CIs) for risk of head and neck cancer in liver transplant recipients were calculated. Tests for heterogeneity, sensitivity, and publishing bias were also performed. Result: Of the 964 identified articles, 10 were deemed eligible. These studies included data on 56,507 patients with a total follow-up of 129,448.9 patient-years. SIR for head and neck cancer was 3.836-fold higher (95% CI 2.754-4.918, P = 0.000) in liver transplant recipients than in the general population. No heterogeneity or publication bias was observed. Sensitivity analysis indicated that omission of any of the studies resulted in an SIR for head and neck cancer between 3.488 (95% CI: 2.379-4.598) and 4.306 (95% CI: 3.020-5.592). Conclusions: Liver transplant recipients are at higher risk of developing head and neck cancer than the general population.
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