期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 49, 期 4, 页码 323-328出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0000000000000170
关键词
chronic hepatitis B; residual amount of HBV DNA; highly sensitive PCR assay; relapse
资金
- Sun Yat-Sen University Clinical Research 5010 Program [2007029]
- National Natural Science Foundation of China [81202319]
- Natural Science Fund of Guangdong Province [S2012040008104]
- Natural Science Foundation of Guangxi [2010GXNSFD013046, 0832037]
- Medical Science Experimental Center Foundation of Guangxi [KFJJ2010-20]
Objective: To investigate the relationship between relapse and the levels of the residual amount of HBV DNA in serum at cessation in chronic hepatitis B patients meeting 2008 Asian Pacific Association for the Study of the Liver (APASL) nucleos(t)ide analogs (NAs) cessation criteria. Methods: A total of 72 chronic hepatitis B patients who took NAs and had reached 2008 APASL cessation criteria entered the study. Patients were followed up for 6 months or longer after antiviral therapy was stopped. Serum HBV DNA level at cessation was detected by a highly sensitive polymerase chain reaction assay with detection limitation of 2 IU/mL. Results: Of all the 72 patients, 42 patients (65.3%) relapsed after NA cessation. The detectable rate of the trace amount of HBV DNA at cessation was 41.7% by highly sensitive polymerase chain reaction reagents. The detectable rate of patients with consolidation treatment duration of <18 months was higher than that with consolidation duration of >= 18 months (47.5% vs. 15.4%, P = 0.034), and the detectable rate of patients with HBeAg sero-conversion within 6 months of treatment was lower than that of >= 6 months (25.0% vs. 61.5%, P = 0.036). The residual amount of HBV DNA and detectable rate at cessation showed significant differences between relapsed and nonrelapsed patients (130.4 +/- 420.90 vs 44.6 +/- 155.16 IU/mL, P = 0.004; 55.3% vs. 16.0%, P = 0.001). The cutoff value predicting relapse was 2.24 IU/mL, with a sensitivity of 0.553 and specificity of 0.840. Conclusions: Residual amount of HBV DNA in serum at NA cessation is associated with HBV relapse. The cutoff value predicting relapse was 2.24 IU/mL, with a sensitivity of 0.553 and specificity of 0.840.
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