期刊
NEUROPSYCHIATRIC DISEASE AND TREATMENT
卷 11, 期 -, 页码 1723-1737出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S84266
关键词
apolipoprotein E; pathogenesis; diseases
资金
- Gachon University Gil Medical Center [2013-22]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), Korea Ministry of Health Welfare [HI14C3331]
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. APOE-dependent alterations of the endocytic pathway can affect different functions. APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-beta peptide, regulating amyloid-beta aggregations and clearances in the brain. Several APOE isoforms with major structural differences were discovered and shown to influence the brain lipid transport, glucose metabolism, neuronal signaling, neuroinflammation, and mitochondrial function. This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans.
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