期刊
BMC BIOINFORMATICS
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2105-12-S8-S8
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资金
- National Institutes of Health National Center for Research Resources [R01RR024031]
- Biotechnology and Biological Sciences Research Council [BB/F010486/1]
- Canadian Institutes of Health Research [FRN 82940]
- European Commission [2007-223411]
- Royal Society
- Scottish Universities Life Sciences Alliance
- National Institutes of Health [1R01RR024031]
- Italian Association for Cancer Research (AIRC)
- Telethon
- EU ENFIN [LSHG-CT-2005-518254]
- PSIMEX [223411]
- Biotechnology and Biological Sciences Research Council [BB/F010486/1] Funding Source: researchfish
- BBSRC [BB/F010486/1] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [23700159] Funding Source: KAKEN
Background: The vast amount of data published in the primary biomedical literature represents a challenge for the automated extraction and codification of individual data elements. Biological databases that rely solely on manual extraction by expert curators are unable to comprehensively annotate the information dispersed across the entire biomedical literature. The development of efficient tools based on natural language processing (NLP) systems is essential for the selection of relevant publications, identification of data attributes and partially automated annotation. One of the tasks of the Biocreative 2010 Challenge III was devoted to the evaluation of NLP systems developed to identify articles for curation and extraction of protein-protein interaction (PPI) data. Results: The Biocreative 2010 competition addressed three tasks: gene normalization, article classification and interaction method identification. The BioGRID and MINT protein interaction databases both participated in the generation of the test publication set for gene normalization, annotated the development and test sets for article classification, and curated the test set for interaction method classification. These test datasets served as a gold standard for the evaluation of data extraction algorithms. Conclusion: The development of efficient tools for extraction of PPI data is a necessary step to achieve full curation of the biomedical literature. NLP systems can in the first instance facilitate expert curation by refining the list of candidate publications that contain PPI data; more ambitiously, NLP approaches may be able to directly extract relevant information from full-text articles for rapid inspection by expert curators. Close collaboration between biological databases and NLP systems developers will continue to facilitate the long-term objectives of both disciplines.
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