期刊
PLATELETS
卷 26, 期 5, 页码 495-497出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/09537104.2014.948838
关键词
Autoimmune thrombocytopenia; beta-galactose; beta-N-acetylglucosamine; oseltamivir; platelet glycoprotein GPIb-IX complex
The management of chronic immune thrombocytopenia (ITP) remains to be a challenge. Oseltamivir phosphate is a sialidase inhibitor agent used to treat influenza in the conventional sense. At present, we demonstrate for the first time that an adult chronic ITP patient with anti-GP lb/IX autoantibody, who was resistant to corticosteroids, IVIG, recombinant human thrombopoietin, rituximab, danazol and vindesine, but was successfully treated with oseltamivir phosphate. Through flow cytometric analysis of beta-galactose and beta-GlcNAc exposure on platelet surfaces, we showed that oseltamivir phosphate could reduce the desialylation level of platelet glycoproteins in ITP patient. The substantial alleviation of thrombocytopenia in this case, though not leading to conclusions, lays a foundation for a novel approach for the treatment of ITP.
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