期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 2, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1006077
关键词
apoptosis; extra virgin olive oil; lysosomal membrane permeabilization; necrosis; oleocanthal
类别
资金
- National Institutes of Health [R01-CA046677, R01-DC02995, R21-DC011393]
- Research Centers in Minority Institutions award - National Center for Research Resources of the National Institute of Health [RP-03037]
- Diversity Supplement [R01-CA046677]
- NATIONAL CANCER INSTITUTE [R01CA179542, R01CA046677] Funding Source: NIH RePORTER
(-)-Oleocanthal (OC), a phenolic compound present in extra-virgin olive oil (EVOO), has been implicated in the health benefits associated with diets rich in EVOO. We investigated the effect of OC on human cancer cell lines in culture and found that OC induced cell death in all cancer cells examined as rapidly as 30 minutes after treatment in the absence of serum. OC treatment of non-transformed cells suppressed their proliferation but did not cause cell death. OC induced both primary necrotic and apoptotic cell death via induction of lysosomal membrane permeabilization (LMP). We provide evidence that OC promotes LMP by inhibiting acid sphingomyelinase (ASM) activity, which destabilizes the interaction between proteins required for lysosomal membrane stability. The data presented here indicate that cancer cells, which tend to have fragile lysosomal membranes compared to non-cancerous cells, are susceptible to cell death induced by lysosomotropic agents. Therefore, targeting lysosomal membrane stability represents a novel approach for the induction of cancer-specific cell death.
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