期刊
WORLD JOURNAL OF DIABETES
卷 6, 期 3, 页码 456-480出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v6.i3.456
关键词
Insulin resistance; Dyslipidemia; Type 2 diabetes mellitus; Oxidative stress
Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, beta-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM. Chronic oxidative stress, hyperglycemia and dyslipidemia are particularly dangerous for beta-cells from lowest levels of antioxidant, have high oxidative energy requirements, decrease the gene expression of key beta-cell genes and induce cell death. If beta-cell functioning is impaired, it results in an under production of insulin, impairs glucose stimulated insulin secretion, fasting hyperglycemia and eventually the development of T2DM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据