期刊
BMB REPORTS
卷 47, 期 9, 页码 506-511出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2014.47.9.265
关键词
Beta-adrenergic receptor; Bone mineral density; High calorie diet; Low calorie diet; Propranolol
资金
- National Research Foundation of Korea (NRF) - Korean government (MEST) [2011-0016548]
- National Research Foundation of Korea [2011-0016548] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We investigated the effects of high calorie and low calorie diets on skeletal integrity, and whether beta-adrenergic blockade (BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either an ad-lib fed control diet (CON), a high calorie diet (HIGH), or a low calorie diet (LOW) group. In each diet group, mice were treated with either vehicle (VEH) or propranolol, a beta-adrenergic antagonist. Over 12-weeks, beta-blockade mitigated body weight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expression levels of osteogenic marker genes in bone marrow cells were reduced in HIGHVEH and LOWVEH mice, and BB significantly attenuated this decline only in HIGH mice. In summary, the magnitude of bone loss induced by low calorie diet was greater than that caused by high calorie diet in growing mice, and beta-blockade mitigated high calorie diet-induced bone loss.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据