期刊
RSC ADVANCES
卷 5, 期 95, 页码 78047-78060出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra16213k
关键词
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资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 480719/2012-8, PVE 401193/2014-4, PQ-SR CNPq 302613/2013-7]
- FAPEMIG [Edital 01/2014]
- CAPES
- FAPERJ
- FAPEAL
- CAPES/PROCAD
- PAPES/Fiocruz
In our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic, triazole-carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold were prepared; in addition to electrochemical studies, these compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Among the thirty-eight compounds herein evaluated, six were found to be more potent against trypomastigotes than the standard drug benznidazole, with IC50/24 h values between 52.9 and 89.5 mu M.
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